Fate and manipulations of endogenous neural stem cells following brain ischemia

Expert Opin Biol Ther. 2009 Sep;9(9):1117-25. doi: 10.1517/14712590903130558.


Stem cells have been proposed as a new form of cell-based therapy in a variety of disorders, including acute and degenerative brain diseases. Endogenous neural stem cells (eNSCs) have been identified in the central nervous system where they reside largely in the subventricular zone and in the subgranular zone of the hippocampus. eNSCs are capable of self-renewal and differentiation into functional glia and neurons throughout life. However, spontaneous brain regeneration does not suffice to induce significant behavioral improvement in acute or chronic brain injury. Nevertheless, eNSCs responses can be considerably increased by tweaking the pathways governing cell proliferation, migration and differentiation. Contemporary evidence now suggests that such perturbations may lead to better functional outcome after brain injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Ischemia / pathology*
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Humans
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Neurons / cytology*
  • Neurons / drug effects
  • Stem Cells / cytology*
  • Stem Cells / drug effects


  • Intercellular Signaling Peptides and Proteins