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. 2009 Oct 9;388(1):161-6.
doi: 10.1016/j.bbrc.2009.07.148. Epub 2009 Aug 3.

Oxytocin deficiency impairs maternal skeletal remodeling

Xuan Liu  1 , Kengo Shimono, Ling-Ling Zhu, Jianhua Li, Yuanzhen Peng, Aliza Imam, Jameel Iqbal, Surinder Moonga, Graziana Colaianni, Cai Su, Zuhong Lu, Masahiro Iwamoto, Maurizio Pacifici, Alberta Zallone, Li Sun, Mone Zaidi
Affiliations

Oxytocin deficiency impairs maternal skeletal remodeling

Xuan Liu et al. Biochem Biophys Res Commun. .

Abstract

We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT(-/-) pups at day E20 also show a defect in trabecular bone. microCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT(-/-) pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.

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