Biomaterials for promoting brain protection, repair and regeneration

Nat Rev Neurosci. 2009 Sep;10(9):682-92. doi: 10.1038/nrn2685. Epub 2009 Aug 5.


Biomaterials are likely to have an increasingly important role in the treatment of nervous system disorders. Recently developed biomaterials can enable and augment the targeted delivery of drugs or therapeutic proteins to the brain, allow cell or tissue transplants to be effectively delivered to the brain and help to rebuild damaged circuits. Similarly, biomaterials are being used to promote regeneration and to repair damaged neuronal pathways in combination with stem cell therapies. Many of these approaches are gaining momentum because nanotechnology allows greater control over material-cell interactions that induce specific developmental processes and cellular responses including differentiation, migration and outgrowth.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / administration & dosage*
  • Biocompatible Materials / chemical synthesis
  • Brain / drug effects
  • Brain / physiology*
  • Brain Diseases / physiopathology
  • Brain Diseases / prevention & control*
  • Humans
  • Nanotechnology / methods
  • Nanotechnology / trends
  • Nerve Regeneration / drug effects
  • Nerve Regeneration / physiology*
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / trends
  • Tissue Engineering / methods
  • Tissue Engineering / trends


  • Biocompatible Materials