Clinical significance of lymph node dissection in patients with muscle-invasive upper urinary tract transitional cell carcinoma treated with nephroureterectomy

J Korean Med Sci. 2009 Aug;24(4):674-8. doi: 10.3346/jkms.2009.24.4.674. Epub 2009 Jul 29.


We investigated the value of lymph node dissection in patients with cN0 muscle-invasive transitional cell carcinoma of the upper urinary tract (UUT-TCC). Medical records of 152 patients with cN0 muscle-invasive UUT-TCC, who underwent nephroureterectomy between 1986 and 2005, were reviewed. Sixty-three patients (41.4%) underwent lymph node dissection. The median number of lymph nodes harvested was 6 (range, 1 to 35), and from these, lymph node involvement was confirmed in 9 patients (14.3%). Locoregional recurrence (LR) and disease-recurrence (DR) occurred in 29 patients and 63 patients, respectively. Fifty-five patients (36.2%) had died of cancer at the last follow-up. The number of lymph nodes harvested was associated with the reduction of LR (chi(2)(trend)=6.755, P=0.009), but was not associated with DR (chi(2)(trend)=1.558, P=0.212). In the survival analysis, N stage (P=0.0251) and lymph node dissection (P=0.0073) had significant influence on LR, but not on DR or disease-specific survival. However, the number of lymph nodes harvested did not affect LR-free, DR-free, or disease-specific survival. We conclude that lymph node dissection may improve the control of locoregional cancer, as well as staging accuracy, in cN0 muscle-invasive UUT-TCC, but that it does not clearly influence survival.

Keywords: Carcinoma, Transitional Cell; Kidney Pelvis; Lymph Node Excision; Recurrence; Ureter.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Transitional Cell / mortality
  • Carcinoma, Transitional Cell / surgery*
  • Carcinoma, Transitional Cell / therapy
  • Female
  • Humans
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / surgery*
  • Kidney Neoplasms / therapy
  • Lymph Node Excision*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Nephrectomy
  • Recurrence
  • Retrospective Studies
  • Survival Analysis
  • Ureteral Neoplasms / mortality
  • Ureteral Neoplasms / surgery*
  • Ureteral Neoplasms / therapy