Functions and modulation of neuronal SK channels

Cell Biochem Biophys. 2009;55(3):127-39. doi: 10.1007/s12013-009-9062-7. Epub 2009 Aug 5.

Abstract

Small conductance (SK) channels are calcium-activated potassium channels that, when cloned in 1996, were thought solely to contribute to the afterhyperpolarisation that follows action potentials, and to control repetitive firing patterns of neurons. However, discoveries over the past few years have identified novel roles for SK channels in controlling dendritic excitability, synaptic transmission and synaptic plasticity. More recently, modulation of SK channel calcium sensitivity by casein kinase 2, and of SK channel trafficking by protein kinase A, have been demonstrated. This article will discuss recent findings regarding the function and modulation of SK channels in central neurons.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Central Nervous System / metabolism
  • Humans
  • Learning / physiology
  • Nervous System Physiological Phenomena
  • Small-Conductance Calcium-Activated Potassium Channels / chemistry*
  • Small-Conductance Calcium-Activated Potassium Channels / metabolism*

Substances

  • Small-Conductance Calcium-Activated Potassium Channels
  • Calcium