Catheter Ablation of Recurrent Scar-Related Ventricular Tachycardia Using Electroanatomical Mapping and Irrigated Ablation Technology: Results of the Prospective Multicenter Euro-VT-study

J Cardiovasc Electrophysiol. 2010 Jan;21(1):47-53. doi: 10.1111/j.1540-8167.2009.01563.x. Epub 2009 Jul 28.

Abstract

Introduction: Ventricular tachycardia (VT) late after myocardial infarction is an important contributor to morbidity and mortality. This prospective multicenter study assessed the efficacy and safety of electroanatomical mapping in combination with open-saline irrigated ablation technology for ablation of chronic recurrent mappable and unmappable VT in remote myocardial infarction.

Methods and results: In 8 European institutions, 63 patients (89% males) were enrolled in the study. All patients had remote myocardial infarction and presented with a median number of 17 (range 1-380) VTs in the preceding 6 months. Incessant VT was present in 14 patients (22%). Left ventricular ejection fraction measured 30 +/- 13%. A mean of 3 VTs were targeted per patient and 22% of all patients had only unmappable VT. The mean follow-up period was 12 +/- 3 months. A total of 164 VTs were targeted during catheter ablation. Ablation was acutely successful in 51 patients (81%). One patient (1.5%) experienced a major complication with degeneration of VT into ventricular fibrillation necessitating cardiopulmonary resuscitation maneuvers. However, no death occurred acutely or within the first 30 days after catheter ablation. During the follow-up, 19 of the initially successful ablated patients (37%) and 31 of all ablated patients (49%) developed some type of VT recurrence.

Conclusions: The results of this multicenter study demonstrate the high acute success rate and a low complication rate of irrigated tip catheter ablation of all clinical relevant VTs in remote myocardial infarction. However, during the follow-up a relevant number of recurrences occurred.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Surface Potential Mapping / methods*
  • Catheter Ablation / methods*
  • Cicatrix / complications
  • Cicatrix / diagnosis*
  • Cicatrix / surgery*
  • Europe
  • Female
  • Humans
  • Hypothermia, Induced / methods
  • Male
  • Middle Aged
  • Prospective Studies
  • Secondary Prevention
  • Tachycardia, Ventricular / diagnosis*
  • Tachycardia, Ventricular / etiology
  • Tachycardia, Ventricular / surgery*
  • Therapeutic Irrigation / methods*
  • Treatment Outcome