Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China

BMC Cancer. 2009 Aug 5;9:269. doi: 10.1186/1471-2407-9-269.

Abstract

Background: Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.

Methods: 600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated.

Results: Increased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39-2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77-2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09-3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01-3.29).

Conclusion: These data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • China
  • Esophageal Neoplasms / diagnosis*
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / mortality
  • Family Health
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Regression Analysis
  • Risk
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / mortality
  • Treatment Outcome