From GH to Billy Ghrelin

Cell Metab. 2009 Aug;10(2):82-3. doi: 10.1016/j.cmet.2009.07.009.

Abstract

The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT).

MeSH terms

  • Acyltransferases / deficiency
  • Acyltransferases / genetics
  • Acyltransferases / metabolism
  • Animals
  • Fasting
  • Ghrelin / genetics
  • Ghrelin / metabolism*
  • Growth Hormone / metabolism*
  • Membrane Proteins
  • Mice
  • Mice, Transgenic
  • Receptors, Ghrelin / metabolism

Substances

  • Ghrelin
  • Membrane Proteins
  • Receptors, Ghrelin
  • Growth Hormone
  • Acyltransferases
  • Mboat4 protein, mouse