Anterior Uveitis Complicating Zoledronic Acid Infusion

Ocul Immunol Inflamm. Jul-Aug 2009;17(4):267-8. doi: 10.1080/09273940902916111.

Abstract

Zoledronic acid is the most effective treatment in patients with hypercalcemia secondary to malignancy; occasionally it can be related to ocular inflammation. We report a case of severe unilateral anterior uveitis following administration of intravenous zoledronic acid in a patient with frontal hyperostosis secondary to breast cancer. The patient developed anterior uveitis 24 hours after the administration of intravenous zoledronate. The patient was treated with topical prednisone and cycloplegic eye drops, with complete recovery after one month. This report shows that, on rare occasions, zoledronic acid can be a possible cause of acute anterior uveitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / administration & dosage
  • Breast Neoplasms / complications*
  • Diphosphonates / administration & dosage*
  • Diphosphonates / adverse effects*
  • Drug Administration Schedule
  • Female
  • Humans
  • Hypercalcemia / drug therapy*
  • Hypercalcemia / etiology*
  • Imidazoles / administration & dosage*
  • Imidazoles / adverse effects*
  • Infusions, Intravenous
  • Ophthalmic Solutions
  • Prednisone / administration & dosage
  • Uveitis, Anterior / chemically induced*
  • Uveitis, Anterior / drug therapy
  • Zoledronic Acid

Substances

  • Anti-Inflammatory Agents
  • Diphosphonates
  • Imidazoles
  • Ophthalmic Solutions
  • Zoledronic Acid
  • Prednisone