Pulmonary manifestations of light chain deposition disease

Respirology. 2009 Jul;14(5):767-70. doi: 10.1111/j.1440-1843.2009.01560.x.

Abstract

Light chain deposition disease (LCDD) is a rare condition characterized by extracellular light chain deposition in tissues. Patients commonly have an underlying plasma cell dyscrasia, and produce excess levels of monoclonal light chains. Renal involvement is the most common clinical manifestation. Rarely, light chains are deposited in the lung. We present the pathologic and radiographic findings of three patients with biopsy-proven pulmonary light chain disease and a review of the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged, 80 and over
  • Biopsy
  • Female
  • Humans
  • Immunoglobulin Light Chains / metabolism*
  • Lung / immunology
  • Lung / pathology
  • Lung Diseases / diagnosis*
  • Lung Diseases / etiology
  • Lung Diseases / immunology*
  • Male
  • Middle Aged
  • Paraproteinemias / complications

Substances

  • Immunoglobulin Light Chains