Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

Biochem Biophys Res Commun. 2009 Oct 16;388(2):261-5. doi: 10.1016/j.bbrc.2009.07.152. Epub 2009 Aug 4.


Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production. In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis / genetics
  • Atherosclerosis / immunology*
  • Atherosclerosis / surgery
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • B-Lymphocytes / immunology
  • Bone Marrow / immunology*
  • Bone Marrow Transplantation / methods
  • Lipoproteins, LDL / immunology
  • Male
  • Mice
  • Mice, Knockout
  • Receptors, Interleukin-17 / genetics
  • Receptors, Interleukin-17 / immunology*
  • Receptors, LDL / genetics
  • Receptors, LDL / immunology*
  • Signal Transduction


  • Autoantibodies
  • Lipoproteins, LDL
  • Receptors, Interleukin-17
  • Receptors, LDL
  • oxidized low density lipoprotein