Glucose enhancement of memory depends on initial thirst

Appetite. 2009 Dec;53(3):426-9. doi: 10.1016/j.appet.2009.07.024. Epub 2009 Aug 4.


This double-blind, placebo-controlled study examined the influence of appetitive state on glucose enhancement of memory. Participants rated their mood, hunger and thirst, then consumed a 25 g glucose drink or a matched placebo 20 min prior to a verbal memory task. There was a double dissociation when the effects of thirst ratings and drink on subsequent memory performance were considered. Those who were initially less thirsty recalled significantly more words following glucose than placebo; those who were more thirsty recalled significantly fewer words after glucose than placebo. Glucose enhancement of memory may therefore critically depend on participants' initial thirst.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affect / physiology
  • Beverages
  • Double-Blind Method
  • Glucose / administration & dosage*
  • Humans
  • Hunger / physiology
  • Memory / drug effects*
  • Placebos
  • Thirst / physiology*


  • Placebos
  • Glucose