Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture

Clin Nutr. 2010 Feb;29(1):78-83. doi: 10.1016/j.clnu.2009.07.003. Epub 2009 Aug 5.

Abstract

Background & aims: In patients with recent hip fracture, reduced serum IGF-I in relation to protein undernutrition is frequent. Elevation of circulating IGF-I in response to a daily oral supplement of 20 g of casein was observed after 6 months. This study determined if the response to casein as compared to whey protein can be observed as early as after one week.

Methods: 45 women were randomized after recent hip fracture in 3 groups receiving a preparation of 20 g of casein, an isocaloric supplement of 20 g of whey protein or an isocaloric supplement of 15 g of whey protein combined with 5 g of essential amino acids (a.a.).

Results: A similar significant elevation of serum IGF-I was already observed after 7 days for casein (+37.3 microg/L), whey (+29.4) and for whey+a.a. (+34.3). From day 7-28, no further significant rise in IGF-I was recorded.

Conclusion: After one week of protein supplementation, the percent increase of IGF-I was of similar magnitude to that previously observed after 6 months of protein supplementation. It suggests that in hip fracture patients, long-term effects of various protein preparations on IGF-I could be predicted from changes observed as early as 7 days after the onset of supplementation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aged, 80 and over
  • Albumins / drug effects
  • Amino Acids, Essential / administration & dosage
  • Amino Acids, Essential / blood
  • Amino Acids, Essential / therapeutic use
  • Analysis of Variance
  • Biomarkers / blood
  • Caseins / administration & dosage
  • Caseins / blood
  • Caseins / therapeutic use
  • Dietary Proteins / administration & dosage
  • Dietary Proteins / blood
  • Dietary Proteins / therapeutic use*
  • Dietary Supplements*
  • Female
  • Follow-Up Studies
  • Geriatric Assessment / methods
  • Hip Fractures / blood*
  • Hip Fractures / complications
  • Humans
  • Insulin-Like Growth Factor I / drug effects
  • Insulin-Like Growth Factor I / metabolism*
  • Milk Proteins / administration & dosage
  • Milk Proteins / blood
  • Milk Proteins / therapeutic use
  • Prealbumin / drug effects
  • Protein-Energy Malnutrition / diet therapy*
  • Protein-Energy Malnutrition / etiology
  • Whey Proteins

Substances

  • Albumins
  • Amino Acids, Essential
  • Biomarkers
  • Caseins
  • Dietary Proteins
  • Milk Proteins
  • Prealbumin
  • Whey Proteins
  • Insulin-Like Growth Factor I