Synthetic approach to telomerase inhibitor dictyodendrin B: synthesis of the pyrrolo[2,3-c]carbazole core

Biosci Biotechnol Biochem. 2009 Aug;73(8):1764-72. doi: 10.1271/bbb.90111. Epub 2009 Aug 7.

Abstract

The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of 3-aryl-1-(2-arylethyl)-4-hydroxy-2,5-bismethoxycarbonylpyrrole triflate with 7-alkoxyindole-3-boronate as the key step.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbazoles / chemical synthesis*
  • Carbazoles / chemistry*
  • Carbazoles / pharmacology
  • Catalysis
  • Palladium / chemistry
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology
  • Reverse Transcriptase Inhibitors / chemical synthesis*
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / pharmacology
  • Telomerase / antagonists & inhibitors*

Substances

  • Carbazoles
  • Pyrroles
  • Reverse Transcriptase Inhibitors
  • dictyodendrin B
  • carbazole
  • Palladium
  • Telomerase