Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines

Nat Prod Res. 2011 Sep;25(15):1444-9. doi: 10.1080/14786410902800665. Epub 2011 Jul 8.

Abstract

In the present investigation, the anti-inflammatory activity of isolated bergapten from hydroalcoholic extract of Heracleum nepalense root was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs). Bergapten exhibited significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α (TNF-α) and interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide in a concentration-dependent manner.

MeSH terms

  • 5-Methoxypsoralen
  • Adult
  • Crystallography, X-Ray
  • Cytokines / antagonists & inhibitors*
  • Cytokines / biosynthesis
  • Heracleum / chemistry*
  • Humans
  • In Vitro Techniques
  • Inflammation Mediators / antagonists & inhibitors*
  • Inflammation Mediators / metabolism
  • Lipopolysaccharides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Methoxsalen / analogs & derivatives*
  • Methoxsalen / pharmacology
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry*
  • Spectrophotometry, Infrared

Substances

  • Cytokines
  • Inflammation Mediators
  • Lipopolysaccharides
  • Plant Extracts
  • 5-Methoxypsoralen
  • Methoxsalen