Abstract
In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC(50) 0.068 microM) and Leishmania infantum (IC(50) 0.79 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annonaceae / chemistry*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology*
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Berberine Alkaloids / chemistry
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Berberine Alkaloids / isolation & purification
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Berberine Alkaloids / pharmacology*
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Leishmania infantum / drug effects*
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology
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Trypanosoma cruzi / drug effects*
Substances
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Antiprotozoal Agents
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Berberine Alkaloids
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Plant Extracts
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Trypanocidal Agents
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palmatine