Efficacy and safety of the combination of docetaxel (Taxotere) with targeted therapies in the treatment of solid malignancies

Curr Drug Targets. 2009 Oct;10(10):982-1000. doi: 10.2174/138945009789578007.


Docetaxel is a chemotherapeutic drug which has recently demonstrated high efficacy in the treatment of a wide variety of tumors. Numerous novel targeted drugs are being introduced in preclinical and clinical practice, aiming to directly inhibit pathways responsible for the maintenance of transformed and immortalized phenotypes of cancer cells. Herein we reported the efficacy and safety results of the most significant clinical trials evaluating different combinations and schedules of docetaxel plus biological therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biological Products / administration & dosage
  • Clinical Trials as Topic
  • Docetaxel
  • Drug Delivery Systems*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology
  • Phenotype
  • Taxoids / administration & dosage


  • Biological Products
  • Taxoids
  • Docetaxel