Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency

Clin Exp Immunol. 2009 Sep;157(3):365-9. doi: 10.1111/j.1365-2249.2009.03973.x.


Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients compared with controls. This was particularly notable in those with low isotype-switched memory B cells, but subset analysis demonstrated no difference when stratified by specific clinical features. We propose that the decreased proportion of iNK T cells in CVID might be linked to the failure of memory B cell generation, which may contribute to reduced antibody production in these patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibody Formation
  • B-Lymphocytes / immunology
  • Case-Control Studies
  • Common Variable Immunodeficiency / immunology*
  • Cryopreservation
  • Flow Cytometry
  • Humans
  • Immunoglobulin Class Switching
  • Immunologic Memory
  • Lymphocyte Activation
  • Lymphocyte Count
  • Natural Killer T-Cells / immunology*
  • Statistics, Nonparametric
  • Time Factors