A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas

Gastroenterology. 2009 Nov;137(5):1698-705. doi: 10.1053/j.gastro.2009.07.061. Epub 2009 Aug 5.


Background & aims: Hepatocellular adenoma (HA) is associated with risk of bleeding and malignancy, justifying resection. Patients with multiple forms of HA are difficult to manage. We evaluated the characteristics and outcome of 122 patients with single and multiple HAs after surgery.

Methods: From 1990 to 2004, 122 patients (14 male) underwent surgical resection. Complications (hemorrhage and malignancy) were assessed according to size, number, and histologic subtype (steatotic, telangiectatic, and unclassified), with a mean follow-up period of 70 months.

Results: Hemorrhagic HA occurred in 21% of cases and malignant HA occurred in 8%. Risk of complications was not related to the number of HAs but was associated with size (>5 cm), especially of telangiectatic and unclassified subtypes. Patients with steatotic HA had a low risk of complications. Malignant HA was more frequent in men (43%); all patients treated by partial resection survived, without recurrent malignancy, after a mean follow-up period of 78 months. After 109 patients with benign HA revealed recurrence or progression of HA in 8% and regression in 9% of cases. No complications were observed in 11 women who became pregnant during the follow-up period.

Conclusions: Patients with HAs greater than 5 cm, telangiectatic or unclassified subtypes, and men have an increased risk of complicated disease; resection should be restricted to these patients. The risk of complications was not related to the number of HAs, so patients with multiple HAs do not need liver transplantation.

MeSH terms

  • Adenoma, Liver Cell / etiology
  • Adenoma, Liver Cell / pathology*
  • Adenoma, Liver Cell / surgery*
  • Adolescent
  • Adult
  • Cohort Studies
  • Female
  • Hepatectomy
  • Humans
  • Liver Neoplasms / etiology
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery*
  • Liver Transplantation
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Young Adult