The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming

Cell Stem Cell. 2009 Aug 7;5(2):141-9. doi: 10.1016/j.stem.2009.07.003.


Pluripotent stem cells have long-term proliferative capacity and an unusual mode of cell-cycle regulation and can divide independently of extrinsic mitogenic signals. The last few years has seen evidence emerge that links cell-cycle regulation to the maintenance and establishment of pluripotency. Myc transcription factors appear to be central to this regulation. This review addresses these links and discusses how cell-cycle controls and Myc impact on the maintenance and establishment of pluripotency.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology*
  • Cell Proliferation
  • Cellular Reprogramming / physiology*
  • Humans
  • Pluripotent Stem Cells / physiology*
  • Proto-Oncogene Proteins c-myc / physiology*


  • Proto-Oncogene Proteins c-myc