Oxidative stress and metabolic changes after continuous positive airway pressure treatment according to previous metabolic disorders in sleep apnea-hypopnea syndrome patients

Transl Res. 2009 Sep;154(3):111-21. doi: 10.1016/j.trsl.2009.06.001. Epub 2009 Jun 27.


Sleep apnea-hypopnea syndrome (SAHS) is characterized by recurrent episodes of hypoxia/reoxygenation, which seems to promote oxidative stress. SAHS patients experience increases in hypertension, obesity, and dyslipidemia, and the oxidative state has been related to the genesis of these disorders. The purpose of this study was to examine the changes in oxidative stress markers and metabolic parameters in S AHS patients after 1 month of treatment with continuous positive airway pressure (CPAP), in relation to their previous metabolic disorders. The study included 78 SAHS patients who required CPAP. The patients were classified according to their disorders, including hypertension, obesity, and dyslipidemia. Measurements were made before and after 1 month of treatment with CPAP. The diastolic blood pressure decreased after treatment in all the patients, significantly so in those who were nondyslipidemic, obese, or hypertensive (the systolic pressure also fell in these latter patients). Plasma oxidative stress biomarkers showed a significant antioxidant capacity and increased activity (P<0.05) after treatment, more so in the nondyslipidemic and hypertensive patients. Furthermore, serum lipid peroxidation levels decreased after CPAP (P<0.01). No change was observed in insulin resistance (IR) after CPAP treatment in any of the different disorders. In conclusion, oxidative stress markers improved significantly after CPAP treatment in SAHS patients, especially in the nondyslipidemic and hypertensive patients. Moreover, the blood pressure decreased after CPAP treatment, particularly in the obese, nondyslipidemic, and hypertensive patients. No significant change in IR was found in any of the SAHS patients after CPAP treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Pressure
  • Continuous Positive Airway Pressure*
  • Dyslipidemias / complications
  • Dyslipidemias / metabolism*
  • Female
  • Humans
  • Hyaluronic Acid / blood
  • Hypertension / complications
  • Hypertension / metabolism
  • Insulin Resistance
  • Lipid Peroxidation / physiology
  • Male
  • Middle Aged
  • Obesity / complications
  • Obesity / metabolism
  • Oxidative Stress / physiology*
  • Sleep Apnea Syndromes / complications
  • Sleep Apnea Syndromes / metabolism*
  • Sleep Apnea Syndromes / therapy*


  • Hyaluronic Acid