Alpha cells beget beta cells

Cell. 2009 Aug 7;138(3):424-6. doi: 10.1016/j.cell.2009.07.022.


Understanding the origins of insulin-producing beta cells of the pancreas could lead to new treatments for diabetes. Collombat et al. (2009) now show that in response to injury, a population of pancreatic progenitor cells can give rise to glucagon-expressing alpha cells that then transdifferentiate into beta cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Glucagon-Secreting Cells / cytology*
  • Insulin-Secreting Cells / cytology*
  • Insulin-Secreting Cells / metabolism
  • Mice
  • Pancreas / cytology*
  • Stem Cells / cytology