Hepatitis E vaccine

Hepatol Int. 2008 Sep;2(3):308-15. doi: 10.1007/s12072-008-9071-4. Epub 2008 Apr 10.


Hepatitis E is an emerging disease in resource-poor regions of the world. It is estimated that about 2 billion people live in areas endemic for this disease. The inability to reproducibly culture hepatitis E virus makes it impossible to develop traditional live or inactivated vaccines. However, significant progress has been made in developing and testing recombinant subunit vaccines based on the viral capsid protein. This review summarizes these efforts.