Chronic hepatitis B: a global health problem requiring coherent worldwide treatment strategies

Hepatol Int. 2007 Jun;1(2):316-25. doi: 10.1007/s12072-007-9006-5. Epub 2007 Jun 6.


Chronic hepatitis B virus infection, a major cause of end-stage liver disease and hepatocellular carcinoma, is a worldwide health concern. While the past two decades have brought major advances in the availability of treatments to help delay or prevent these outcomes, treatment of chronic hepatitis B remains a serious challenge, not least due to the ability of the virus to remain in hepatocyte nuclei as a source of potential reactivation-hence the term chronic hepatitis B infection. This article reviews the current treatments available and suggests a framework for a rational approach to managing the disease.