Association between cardio-ankle vascular index and serum cystatin C levels in patients with cardiovascular risk factor

J Atheroscler Thromb. 2009 Aug;16(4):371-9. doi: 10.5551/jat.no687. Epub 2009 Aug 11.


Aim: The aim of this study was to clarify the relationship between CAVI and serum cystatin C levels to understand the role of arterial stiffness in the presence of renal insufficiency.

Methods: We enrolled 206 consecutive patients with cardiovascular risk factors and/or coronary artery disease (CAD) in the study. Serum cystatin C, estimated glomerular filtration rate (eGFR), and plasma levels of von Willebrand factor (vWF) and plasminogen activator inhibitor (PAI-1) were measured. CAVI was determined as an index of arterial stiffness.

Results: For all patients, the mean serum cystatin C level was 0.81+/-0.21 mg/L and mean eGFR was 65.8+/-15.5 mL/min per 1.73 m(2). In univariate analysis, CAVI levels significantly correlated with cystatin C levels (r=0.414, p<0.001), eGFR (r=-0.315, p<0.01), PAI-1 (r=0.269, p<0.01), and vWF (r=0.207, p<0.01). Multiple regression analysis showed that age, cystatin C, PAI-1, and a history of CAD were independent variables of CAVI. Age-adjusted CAVI was highest in the presence of both CAD and renal impairment.

Conclusion: CAVI was closely associated with cystatin C levels. These results suggest a significant role of arterial stiffness in renal insufficiency.

MeSH terms

  • Aged
  • Ankle / blood supply
  • Brachial Artery / physiopathology
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / diagnosis
  • Cystatin C / blood*
  • Diagnostic Techniques, Cardiovascular*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Renal Insufficiency / physiopathology
  • Risk Factors
  • Vascular Resistance


  • Cystatin C