Tamoxifen: the drug that came in from the cold

Br J Cancer. 2009 Sep 15;101(6):875-8. doi: 10.1038/sj.bjc.6605231. Epub 2009 Aug 11.

Abstract

Despite the perception of many oncologists that tamoxifen is an inferior drug, and should be substituted by an aromatase inhibitor in post-menopausal women, the current evidence strongly supports the view that AIs should be used 2-3 years after tamoxifen to achieve the maximal overall survival (OS) advantage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aromatase Inhibitors / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / mortality
  • Clinical Trials as Topic
  • Estrogen Antagonists / therapeutic use*
  • Female
  • Humans
  • Tamoxifen / therapeutic use*

Substances

  • Aromatase Inhibitors
  • Estrogen Antagonists
  • Tamoxifen