Fluorinated lipid constructs permit facile passage of molecular cargo into living cells

J Am Chem Soc. 2009 Sep 2;131(34):12091-3. doi: 10.1021/ja902777d.


Fluorinated lipids get rapidly internalized into living cells and are also displayed on the cell surface. The uptake of lipids is energy dependent and is likely via the clathrin-mediated endocytic pathway. Fluorinated lipids are 3-5-fold more efficient in acting as molecular transporters of noncovalently bound proteins than their hydrocarbon counterparts. These materials could serve as efficient molecular transporters for molecules that function in the cytoplasm such as short interfering RNAs (siRNAs).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biological Transport
  • Cell Survival
  • Endocytosis*
  • Flow Cytometry
  • Halogenation*
  • HeLa Cells
  • Humans
  • Microscopy, Fluorescence
  • Phosphatidylethanolamines / chemistry*
  • Phosphatidylethanolamines / metabolism*


  • Phosphatidylethanolamines
  • 1,2-dipalmitoyl-3-phosphatidylethanolamine