Function and biogenesis of iron-sulphur proteins

Nature. 2009 Aug 13;460(7257):831-8. doi: 10.1038/nature08301.


Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / metabolism
  • Cell Nucleus / metabolism
  • Cytosol / metabolism
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Iron-Sulfur Proteins / biosynthesis*
  • Mitochondria / metabolism
  • Plastids / metabolism


  • Iron-Sulfur Proteins