Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Aug 13;460(7257):839-47.
doi: 10.1038/nature08302.

Molybdenum Cofactors, Enzymes and Pathways


Molybdenum Cofactors, Enzymes and Pathways

Günter Schwarz et al. Nature. .


The trace element molybdenum is essential for nearly all organisms and forms the catalytic centre of a large variety of enzymes such as nitrogenase, nitrate reductases, sulphite oxidase and xanthine oxidoreductases. Nature has developed two scaffolds holding molybdenum in place, the iron-molybdenum cofactor and pterin-based molybdenum cofactors. Despite the different structures and functions of molybdenum-dependent enzymes, there are important similarities, which we highlight here. The biosynthetic pathways leading to both types of cofactor have common mechanistic aspects relating to scaffold formation, metal activation and cofactor insertion into apoenzymes, and have served as an evolutionary 'toolbox' to mediate additional cellular functions in eukaryotic metabolism.

Similar articles

See all similar articles

Cited by 157 articles

See all "Cited by" articles


    1. J Biol Chem. 2004 Oct 1;279(40):41398-403 - PubMed
    1. J Mol Biol. 2008 Jun 13;379(4):881-99 - PubMed
    1. J Biol Chem. 2001 Jun 22;276(25):22024-31 - PubMed
    1. Hum Mol Genet. 2004 Jun 15;13(12):1249-55 - PubMed
    1. Nature. 1997 May 22;387(6631):370-6 - PubMed

Publication types

LinkOut - more resources