Abstract
The synthesis, characterization and in vitro anti-HIV activity of a series of generation one dendrimers having phosphonate groups with pendant alkyl chains are described. The influence of the lateral alkyl chains on the biological properties was correlated to (1)H-(1)H NOESY experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology
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Cell Line
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Dendrimers / chemical synthesis
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Dendrimers / chemistry*
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Dendrimers / pharmacology
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HIV-1 / drug effects*
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Humans
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Magnetic Resonance Spectroscopy
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Organophosphonates / chemistry*
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Structure-Activity Relationship
Substances
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Anti-HIV Agents
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Dendrimers
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Organophosphonates