Vaccination as a triggering event for autoimmune hepatitis

Semin Liver Dis. 2009 Aug;29(3):331-4. doi: 10.1055/s-0029-1233537. Epub 2009 Aug 12.


The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks. Implicated triggering factors are numerous and include toxins, medications, and infectious agents. In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination. All evidence suggests this was an idiosyncratic response to either hepatitis A or yellow fever vaccination.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers / blood
  • Biopsy, Needle
  • Drug Therapy, Combination
  • Female
  • Hepatitis A Vaccines / adverse effects*
  • Hepatitis, Autoimmune / diagnosis
  • Hepatitis, Autoimmune / drug therapy
  • Hepatitis, Autoimmune / etiology*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Liver / pathology
  • Treatment Outcome
  • Yellow Fever Vaccine / adverse effects*


  • Biomarkers
  • Hepatitis A Vaccines
  • Immunosuppressive Agents
  • Yellow Fever Vaccine