Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer

Lancet. 1990 Jan 27;335(8683):193-5. doi: 10.1016/0140-6736(90)90279-e.


Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.

Publication types

  • Review

MeSH terms

  • Campylobacter / enzymology*
  • Campylobacter Infections / complications*
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology*
  • Humans
  • Stomach Ulcer / etiology*
  • Stomach Ulcer / metabolism
  • Stomach Ulcer / pathology
  • Urease / metabolism*


  • Urease