Review
doi: 10.1038/343425a0.
Regulation of the mevalonate pathway
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- PMID: 1967820
- DOI: 10.1038/343425a0
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Review
Regulation of the mevalonate pathway
Nature.
.
Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
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