Regulation of the Mevalonate Pathway

Nature. 1990 Feb 1;343(6257):425-30. doi: 10.1038/343425a0.

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cholesterol / biosynthesis
  • Farnesol / metabolism
  • Gene Expression Regulation / drug effects
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / genetics
  • Hydroxymethylglutaryl-CoA Synthase / genetics
  • Mevalonic Acid / metabolism*
  • Receptors, LDL / genetics
  • Sterols / pharmacology
  • Transcription, Genetic / drug effects

Substances

  • Receptors, LDL
  • Sterols
  • Farnesol
  • Cholesterol
  • Hydroxymethylglutaryl CoA Reductases
  • Hydroxymethylglutaryl-CoA Synthase
  • Mevalonic Acid