Viscerotropic disease following yellow fever vaccination in Peru

Vaccine. 2009 Oct 9;27(43):5974-81. doi: 10.1016/j.vaccine.2009.07.082. Epub 2009 Aug 11.


Five suspected cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) clustered in space and time following a vaccination campaign in Ica, Peru in 2007. All five people received the same lot of 17DD live attenuated yellow fever vaccine before their illness; four of the five died of confirmed YEL-AVD. The surviving case was classified as probable YEL-AVD. Intensive investigation yielded no abnormalities of the implicated vaccine lot and no common risk factors. This is the first described space-time cluster of yellow fever viscerotropic disease involving more than two cases. Mass yellow fever vaccination should be avoided in areas that present extremely low risk of yellow fever.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Fatal Outcome
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peru
  • Risk Factors
  • Vaccination / adverse effects*
  • Vaccines, Attenuated / adverse effects
  • Yellow Fever / prevention & control*
  • Yellow Fever Vaccine / adverse effects*
  • Young Adult


  • Vaccines, Attenuated
  • Yellow Fever Vaccine