A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

Cell. 1990 Feb 23;60(4):547-55. doi: 10.1016/0092-8674(90)90658-2.


It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell acute lymphoblastic leukemias, is within the E2A transcription factor gene on chromosome 19. A cell line with this translocation contains two novel chimeric mRNAs, both with the same 5'E2A sequences but with different lengths of 3' sequence from a previously unrecognized gene dubbed prl, located on chromosome 1. The chimeric RNAs encode a protein that lacks 171 amino acids of E2A, including its DNA binding and dimerization motifs, but have instead a homeobox-related sequence from prl. Therefore, the production of a chimeric E2A-Prl protein may contribute to the acute lymphoblastic phenotype by directly altering the expression of genes normally responsive to the Prl homeoprotein.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Burkitt Lymphoma / genetics*
  • Cell Line
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 19*
  • Cloning, Molecular
  • DNA, Neoplasm / genetics
  • DNA-Binding Proteins / genetics*
  • Genes, Homeobox*
  • Humans
  • Molecular Sequence Data
  • Preleukemia / genetics*
  • Protein Conformation
  • RNA, Messenger / genetics
  • Sequence Homology, Nucleic Acid
  • Transcription Factors / genetics
  • Translocation, Genetic*


  • DNA, Neoplasm
  • DNA-Binding Proteins
  • RNA, Messenger
  • Transcription Factors

Associated data

  • GENBANK/M31522
  • GENBANK/M31523
  • GENBANK/M31654