Management of arterial hypertension occurring early after living donor liver transplantation in children: report of three cases and review of the literature

Pediatr Cardiol. 2009 Nov;30(8):1161-5. doi: 10.1007/s00246-009-9498-y. Epub 2009 Aug 13.

Abstract

Three pediatric patients with hypertension occurring early after liver transplantation are reviewed. The patients were all female, and underwent living donor liver transplantation at the age of 9 years, 1 month, and 7 months. The etiology of liver disease was cirrhosis due to biliary atresia in two patients and fulminant hepatitis in one patient. Antihypertensive therapy with calcium channel blocker alone was not effective. Blood pressure was eventually controlled after the administration of a beta-adrenergic blocker in addition to the calcium channel blocker to all patients. No end-organ damage was observed, except that two patients developed temporary left ventricular hypertrophy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Age Factors
  • Antihypertensive Agents / therapeutic use*
  • Calcium Channel Blockers / therapeutic use
  • Child
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension / drug therapy
  • Hypertension / etiology*
  • Infant
  • Liver Transplantation / adverse effects*
  • Living Donors
  • Time Factors

Substances

  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Calcium Channel Blockers