Modulation of inflammation through IL-17 production by gammadelta T cells: mandatory in the mouse, dispensable in humans?

Immunol Lett. 2009 Dec 2;127(1):8-12. doi: 10.1016/j.imlet.2009.08.003. Epub 2009 Aug 12.


Recent studies suggest that gammadelta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gammadelta T cells and highlight the similarities and differences between murine gammadelta T cells and their human counterparts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis
  • Disease Models, Animal
  • Humans
  • Immunity, Cellular*
  • Infections / immunology
  • Inflammation Mediators / metabolism
  • Interleukin-17 / biosynthesis*
  • Interleukin-17 / genetics
  • Mice
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocyte Subsets / metabolism*
  • T-Lymphocyte Subsets / pathology


  • Antigens, CD
  • Inflammation Mediators
  • Interleukin-17
  • Receptors, Antigen, T-Cell, gamma-delta