Gastric acid inhibition for fat malabsorption or gastroesophageal reflux disease in cystic fibrosis: longitudinal effect on bacterial colonization and pulmonary function

J Pediatr. 2009 Nov;155(5):629-33. doi: 10.1016/j.jpeds.2009.06.040. Epub 2009 Aug 14.


Objectives: To investigate bacterial colonization and pulmonary function longitudinally in patients with cystic fibrosis (CF) receiving drugs for gastric acid (GA) inhibition for fat malabsorption or for gastroesophageal reflux disease (GERD).

Study design: A retrospective cohort study of 218 pediatric patients with CF was performed. Multilevel modeling was used to perform longitudinal analysis of forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC), maximum expiratory flow at 50% of FVC (MEF(50)), and maximal mid-expiratory flow between 25% and 75% of FVC (MMEF(25-75)). Cox regression was used to calculate Pseudomonas aeruginosa- and Staphylococcus aureus-free survival.

Results: Patients with CF and GA inhibition had a significantly smaller yearly decline of MEF(50) and MMEF(25-75) compared with control subjects. Other pulmonary function parameters and P aeruginosa or S aureus acquisition or colonization were not different from that of control subjects. GERD was associated with a significantly reduced pulmonary function (FEV(1) and FVC) and an earlier acquisition of P aeruginosa and S aureus.

Conclusions: GA inhibition did not affect pulmonary function or bacterial acquisition and therefore is not contraindicated in patients with CF. GA inhibition might improve pulmonary function with time, because the decline of MEF(50) and MMEF(25-75) was less pronounced. GERD was associated with a reduced pulmonary function and an earlier acquisition of P aeruginosa and S aureus. Therefore the diagnosis and treatment of GERD should be aggressively pursued in patients with CF.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adolescent
  • Child
  • Cohort Studies
  • Colony Count, Microbial
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis / microbiology*
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume / drug effects
  • Forced Expiratory Volume / physiology
  • Gastric Acid / metabolism
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Infant
  • Infant, Newborn
  • Longitudinal Studies
  • Malabsorption Syndromes / complications
  • Malabsorption Syndromes / diagnosis
  • Malabsorption Syndromes / drug therapy*
  • Male
  • Multivariate Analysis
  • Odds Ratio
  • Probability
  • Proportional Hazards Models
  • Proton Pump Inhibitors / therapeutic use*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / isolation & purification*
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / isolation & purification*
  • Treatment Outcome
  • Vital Capacity / drug effects


  • Proton Pump Inhibitors