Abstract
Enaminonitrile 2 was used as key intermediate for the synthesis of polyfunctionally substituted heterocycles (e.g. pyrazoles, isoxazole, pyrimidines, thiazolo[3,2-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, pyrido[1,2-a]pyrimidine, 1,5-benzodiazepine, and pyrazolo[1,5-a]pyrimidine) incorporating benzothiazole moiety via its reactions with some N-nucleophiles. The newly synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Antifungal Agents* / chemical synthesis
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Antifungal Agents* / chemistry
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Antifungal Agents* / pharmacology
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Bacteria / drug effects*
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Botrytis / drug effects*
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Drug Design
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Fusarium / drug effects*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds, 2-Ring / chemical synthesis*
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Heterocyclic Compounds, 2-Ring / chemistry
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Heterocyclic Compounds, 2-Ring / pharmacology
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Isoxazoles / chemical synthesis
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Isoxazoles / chemistry
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Microbial Sensitivity Tests
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Molecular Structure
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Nitriles / pharmacology
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Benzothiazoles
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Heterocyclic Compounds
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Heterocyclic Compounds, 2-Ring
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Isoxazoles
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Nitriles
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Pyrazoles
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Pyrimidines
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enaminonitrile
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benzothiazole