[Involvement of CNS in leukaemia and lymphomas--CSF meningeosis and immunocytochemical phenotyping]

Fortschr Neurol Psychiatr. 2009 Aug;77 Suppl 1:S37-8. doi: 10.1055/s-0028-1109600. Epub 2009 Aug 14.
[Article in German]


The detection of tumour cells in the cerebrospinal fluid (CSF) of leukaemia and lymphoma patients is a challenge for CSF cytological investigation. Nevertheless, it is generally possible to confirm the involvement of the central nervous system (CNS) by conventional microscopic detection of tumour cells. Immunocytochemical staining techniques are a valuable complement of conventional cytology. Immunocytochemical cell phenotyping is indicated for identification of atypical cells in patients with suspected primary CNS lymphoma or malignant haematological disease.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Central Nervous System Diseases / cerebrospinal fluid
  • Central Nervous System Diseases / classification
  • Central Nervous System Diseases / etiology*
  • Humans
  • Immunohistochemistry
  • Leukemia / cerebrospinal fluid
  • Leukemia / classification
  • Leukemia / complications*
  • Lymphoma / cerebrospinal fluid
  • Lymphoma / classification
  • Lymphoma / complications*
  • Phenotype
  • World Health Organization