Well-differentiated and dedifferentiated liposarcomas

Virchows Arch. 2010 Feb;456(2):167-79. doi: 10.1007/s00428-009-0815-x. Epub 2009 Aug 18.


Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

Publication types

  • Review

MeSH terms

  • Cyclin-Dependent Kinase 4 / genetics
  • Gene Amplification / genetics
  • Humans
  • Karyotyping
  • Liposarcoma / diagnosis
  • Liposarcoma / genetics*
  • Liposarcoma / pathology
  • Prognosis
  • Proto-Oncogene Proteins c-mdm2 / genetics


  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Cyclin-Dependent Kinase 4