[Study on the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases]

Wei Sheng Yan Jiu. 2009 Jul;38(4):401-4.
[Article in Chinese]

Abstract

Objective: To explore the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases (NFLD).

Methods: A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect FABP2 Ala54Thr genotypes. The cases and controls were interviewed by using the same questionnaire.

Results: The genotype frequencies of Ala54Ala, Ala54Thr and Thr54Thr were 39.7%, 46.6% and 13.7% in cases, and 48.5%, 43.1% and 8.4% in controls. The Thr allele frequency in cases (36.97%) was higher than that in the controls (29.94%)(P = 0.01). Multiple logistic regression results showed that after adjusting other confound factors, the Thr54 Thr genotype was the independent risk factor of NFLD (OR = 1.97, 95% CI: 1.18-3.35).

Conclusion: FABP2 Thr54Thr genotype might increase the risk of NFLD development.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alanine / genetics
  • Amino Acid Substitution
  • Case-Control Studies
  • Fatty Acid-Binding Proteins / genetics*
  • Fatty Liver / etiology
  • Fatty Liver / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Risk Factors
  • Threonine / genetics
  • Young Adult

Substances

  • FABP2 protein, human
  • Fatty Acid-Binding Proteins
  • Threonine
  • Alanine