Hyperthermia exacerbates ischaemic brain injury

Int J Stroke. 2009 Aug;4(4):274-84. doi: 10.1111/j.1747-4949.2009.00317.x.


Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Body Temperature Regulation / physiology
  • Brain / pathology
  • Brain Ischemia / complications*
  • Brain Ischemia / metabolism
  • Brain Ischemia / pathology
  • Fever / complications*
  • Fever / metabolism
  • Humans
  • Infections / complications
  • Neuroprotective Agents / therapeutic use
  • Stroke / etiology*
  • Stroke / pathology
  • Thrombolytic Therapy
  • Treatment Outcome


  • Neuroprotective Agents