Synergistic effect of prostaglandin E1 and isosorbide dinitrate in peripheral vascular disease

Lancet. 1990 Mar 17;335(8690):627-8. doi: 10.1016/0140-6736(90)90412-x.

Abstract

Isosorbide dinitrate, which releases nitric oxide in vivo, and prostaglandin E1 synergised in reducing platelet deposition and increasing platelet survival time in patients with peripheral vascular disease.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arteriosclerosis / blood*
  • Arteriosclerosis / complications
  • Coronary Disease / blood*
  • Coronary Disease / complications
  • Drug Administration Schedule
  • Drug Evaluation
  • Drug Synergism
  • Female
  • Humans
  • Isosorbide Dinitrate / administration & dosage
  • Isosorbide Dinitrate / pharmacology*
  • Male
  • Middle Aged
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Count / drug effects*
  • Prostaglandins E / administration & dosage
  • Prostaglandins E / pharmacology*
  • Randomized Controlled Trials as Topic

Substances

  • Platelet Aggregation Inhibitors
  • Prostaglandins E
  • Isosorbide Dinitrate