Alpha-ketoglutarate and postoperative muscle catabolism

J Wernerman; F Hammarqvist; E Vinnars

doi:10.1016/0140-6736(90)90811-i

Alpha-ketoglutarate and postoperative muscle catabolism

Lancet. 1990 Mar 24;335(8691):701-3. doi: 10.1016/0140-6736(90)90811-i.

Authors

J Wernerman¹, F Hammarqvist, E Vinnars

Affiliation

¹ Department of Anaesthesiology and Intensive Care, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.

PMID: 1969067
DOI: 10.1016/0140-6736(90)90811-i

Abstract

The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cholecystectomy
Drug Evaluation
Glutamine / metabolism*
Humans
Ketoglutaric Acids / administration & dosage
Ketoglutaric Acids / pharmacology*
Muscle Proteins / metabolism*
Nitrogen / urine*
Parenteral Nutrition, Total*
Postoperative Period
Ribosomes / metabolism

Substances

Ketoglutaric Acids
Muscle Proteins
Glutamine
Nitrogen