Abstract
The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholecystectomy
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Drug Evaluation
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Glutamine / metabolism*
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Humans
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Ketoglutaric Acids / administration & dosage
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Ketoglutaric Acids / pharmacology*
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Muscle Proteins / metabolism*
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Nitrogen / urine*
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Parenteral Nutrition, Total*
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Postoperative Period
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Ribosomes / metabolism
Substances
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Ketoglutaric Acids
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Muscle Proteins
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Glutamine
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Nitrogen