Alpha-ketoglutarate and postoperative muscle catabolism

Lancet. 1990 Mar 24;335(8691):701-3. doi: 10.1016/0140-6736(90)90811-i.


The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholecystectomy
  • Drug Evaluation
  • Glutamine / metabolism*
  • Humans
  • Ketoglutaric Acids / administration & dosage
  • Ketoglutaric Acids / pharmacology*
  • Muscle Proteins / metabolism*
  • Nitrogen / urine*
  • Parenteral Nutrition, Total*
  • Postoperative Period
  • Ribosomes / metabolism


  • Ketoglutaric Acids
  • Muscle Proteins
  • Glutamine
  • Nitrogen