Case of inflammatory fibroid polyp of the esophagogastric junction

Dig Endosc. 2009 Apr;21(2):97-100. doi: 10.1111/j.1443-1661.2009.00833.x.


Upper gastrointestinal endoscopy of a 25-year-old man with heartburn revealed an elevated lesion in the esophagogastric junction (EGJ). Piecemeal endoscopic mucosal resection (EMR) followed by histopathological examination led to a diagnosis of inflammatory fibroid polyp (IFP). After EMR, the heartburn persisted despite giving a proton pump inhibitor (PPI), and the residual lesion gradually enlarged and a transverse mucosal break developed on the esophageal side of it. However, the combined administration of the PPI and an H2 receptor antagonist reduced the heartburn, and led to endoscopic regression of the lesion and disappearance of the transverse mucosal break. IFP of the esophagogastric junction is extremely rare, and this case is interesting in that potent inhibition of gastric acid secretion resulted in the regression of the lesion.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Esophageal Diseases / drug therapy
  • Esophageal Diseases / pathology*
  • Esophageal Diseases / surgery
  • Esophagogastric Junction*
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Male
  • Polyps / drug therapy
  • Polyps / pathology*
  • Polyps / surgery*
  • Proton Pump Inhibitors / radiation effects
  • Proton Pump Inhibitors / therapeutic use
  • Stomach Diseases / drug therapy
  • Stomach Diseases / pathology*
  • Stomach Diseases / surgery


  • Histamine H2 Antagonists
  • Proton Pump Inhibitors