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, 19 (18), 5346-50

Design and Synthesis of Piperazinylpyrimidinones as Novel Selective 5-HT(2C) Agonists

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Design and Synthesis of Piperazinylpyrimidinones as Novel Selective 5-HT(2C) Agonists

Mark D Andrews et al. Bioorg Med Chem Lett.

Abstract

This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT(2C) agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT(2A) and 5-HT(2B) receptors. Compound 11 was active in in vivo models of stress urinary incontinence.

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