Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis

Kidney Int. 2009 Nov;76(9):991-8. doi: 10.1038/ki.2009.298. Epub 2009 Aug 19.


We studied the incidence and progression of coronary artery calcification in people with early chronic kidney disease. We used a cohort of 562 adult patients with chronic kidney disease who had an estimated glomerular filtration rate of <60 ml/min/1.73 m(2), in a community-based study of people without clinical cardiovascular disease, the Multi-Ethnic Study of Atherosclerosis. The majority had stage 3 disease. Coronary artery calcification was measured at baseline and again approximately 1.6 or 3.2 years later. The prevalence of coronary artery calcification at baseline was 66%, and its adjusted prevalence was 24% lower in African Americans as compared to Caucasians. The incidence of coronary artery calcification was 6.1% per year in women and 14.8% in men. Coronary artery calcification progressed in approximately 17% of subjects per year across all subgroups, and diabetes was associated with a 65% greater adjusted risk of progression. Male gender and diabetes were the only factors associated with adjusted coronary artery calcification incidence and progression, respectively. Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • African Continental Ancestry Group / statistics & numerical data
  • Aged
  • Asian Continental Ancestry Group / statistics & numerical data
  • Calcinosis / diagnosis
  • Calcinosis / ethnology
  • Calcinosis / etiology*
  • Chronic Disease
  • Cohort Studies
  • Continental Population Groups / statistics & numerical data*
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / ethnology
  • Coronary Artery Disease / etiology*
  • Diabetes Complications / ethnology
  • Diabetes Complications / etiology
  • Disease Progression
  • European Continental Ancestry Group / statistics & numerical data
  • Female
  • Hispanic Americans / statistics & numerical data
  • Humans
  • Incidence
  • Kidney Diseases / complications*
  • Kidney Diseases / diagnosis
  • Kidney Diseases / ethnology
  • Linear Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Time Factors
  • United States / epidemiology