WNTs tune up the neuromuscular junction

Nat Rev Neurosci. 2009 Sep;10(9):627-34. doi: 10.1038/nrn2681.


Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Neuromuscular Junction / chemistry
  • Neuromuscular Junction / physiology*
  • Neuronal Plasticity / physiology
  • Signal Transduction / physiology
  • Synapses / chemistry
  • Synapses / physiology*
  • Synaptic Transmission / physiology
  • Wnt Proteins / chemistry
  • Wnt Proteins / physiology*


  • Wnt Proteins